Covid-19 VACCINE News

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Re: Covid-19 VACCINE News

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Intradermal Covid vaccination in Phuket
published : 24 Sep 2021 at 17:44
writer: Achadthaya Chuenniran

PHUKET: The Public Health Ministry began intradermal Covid-19 vaccination as a booster in this southern province on Friday, saying a normal dose could be stretched to inoculate five times as many people as by intramuscular injection.

Dr Withita Jaeng-iam, deputy director of Vachira Phuket Hospital, said intradermal injection started in Phuket with the Covid-19 vaccine made by AstraZeneca as the third and booster shot.

The injection into skin was administered at six local inoculation stations with a combined capacity of vaccinating more than 8,000 people a day, she said.

Intradermal injection used one-fifth of the dose normally given to one person by intramuscular injection. Therefore, vaccination could cover more people faster, Dr Withita said.

Thai and foreigners were highly interested in intradermal injection, Dr Withita said.

Local and international research had found that it was as effective as intramuscular injection and with fewer side effects, accordig to Dr Withita.
https://www.bangkokpost.com/thailand/ge ... -in-phuket
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Chuck Borris
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Re: Covid-19 VACCINE News

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CEOCambodiaNews wrote: Sat Sep 25, 2021 12:56 am Intradermal Covid vaccination in Phuket
published : 24 Sep 2021 at 17:44
writer: Achadthaya Chuenniran

PHUKET: The Public Health Ministry began intradermal Covid-19 vaccination as a booster in this southern province on Friday, saying a normal dose could be stretched to inoculate five times as many people as by intramuscular injection.

Dr Withita Jaeng-iam, deputy director of Vachira Phuket Hospital, said intradermal injection started in Phuket with the Covid-19 vaccine made by AstraZeneca as the third and booster shot.

The injection into skin was administered at six local inoculation stations with a combined capacity of vaccinating more than 8,000 people a day, she said.

Intradermal injection used one-fifth of the dose normally given to one person by intramuscular injection. Therefore, vaccination could cover more people faster, Dr Withita said.


Thai and foreigners were highly interested in intradermal injection, Dr Withita said.

Local and international research had found that it was as effective as intramuscular injection and with fewer side effects, accordig to Dr Withita.
https://www.bangkokpost.com/thailand/ge ... -in-phuket
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Re: Covid-19 VACCINE News

Post by nerdlinger »

Chuck Borris wrote: Sat Sep 25, 2021 1:30 am
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My sentiments exactly. I’m not saying this is bollocks but it does seem weird that the first time I’m hearing of this is from the deputy head of some hospital in Phuket. Are there any actual studies on this?
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Re: Covid-19 VACCINE News

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Quite a bit of information on this topic, eg:

Immunogenicity and Safety of Reduced-Dose Intradermal vs Intramuscular Influenza Vaccines: A Systematic Review and Meta-analysis

Abstract

Importance: Low-dose intradermal influenza vaccines could be a suitable alternative to full intramuscular dose during vaccine shortages.

Objective: To compare the immunogenicity and safety of the influenza vaccine at reduced or full intradermal doses with full intramuscular doses to inform policy design in the event of vaccine shortages.

Results: A total of 30 relevant studies were included; 29 studies were randomized clinical trials with 13 759 total participants, and 1 study was a cohort study of 164 021 participants. There was no statistically significant difference in seroconversion rates between the 3-µg, 6-µg, 7.5-µg, and 9-µg intradermal vaccine doses and the 15-µg intramuscular vaccine dose for each of the H1N1, H3N2, and B strains, but rates were significantly higher with the 15-µg intradermal dose compared with the 15-µg intramuscular dose for the H1N1 strain (rate ratio [RR], 1.10; 95% CI, 1.01-1.20) and B strain (RR, 1.40; 95% CI, 1.13-1.73). Seroprotection rates for the 9-µg and 15-µg intradermal doses did not vary significantly compared with the 15-µg intramuscular dose for all the 3 strains, except for the 15-µg intradermal dose for the H1N1 strain, for which rates were significantly higher (RR, 1.05; 95% CI, 1.01-1.09). Local adverse events were significantly higher with intradermal doses than with the 15-µg intramuscular dose, particularly erythema (3-µg dose: RR, 9.62; 95% CI, 1.07-86.56; 6-µg dose: RR, 23.79; 95% CI, 14.42-39.23; 9-µg dose: RR, 4.56; 95% CI, 3.05-6.82; 15-µg dose: RR, 3.68; 95% CI, 3.19-4.25) and swelling (3-µg dose: RR, 20.16; 95% CI, 4.68-86.82; 9-µg dose: RR, 5.23; 95% CI, 3.58-7.62; 15-µg dose: RR, 3.47 ; 95% CI, 2.21-5.45). Fever and chills were significantly more common with the 9-µg intradermal dose than the 15-µg intramuscular dose (fever: RR, 1.36; 95% CI, 1.03-1.80; chills: RR, 1.24; 95% CI, 1.03-1.50) while all other systemic adverse events were not statistically significant for all other doses.

Conclusions and relevance: These findings suggest that reduced-dose intradermal influenza vaccination could be a reasonable alternative to standard dose intramuscular vaccination.

https://pubmed.ncbi.nlm.nih.gov/33560425/

Here's one from 1998:

Low-dose intradermal versus intramuscular administration of recombinant hepatitis B vaccine: a comparison of immunogenicity in infants and preschool children

https://pubmed.ncbi.nlm.nih.gov/9711797/
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Re: Covid-19 VACCINE News

Post by newkidontheblock »

The studies basically say (to me) that as a shot recipient, the intra dermal shot will hurt more, and will feel worse than after a standard shot.

Also notice the couching of the conclusions. It may be a reasonable approach for mass immunization in third world countries with limited resources.

Not that a worldwide flat out replacement for the standard IM shot.

Just my opinion.

But it will interesting to see the results.
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Re: Covid-19 VACCINE News

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In a nation run by swine, all pigs are upward-mobile and the rest of us are fucked until we can put our acts together: not necessarily to win, but mainly to keep from losing completely. HST
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Re: Covid-19 VACCINE News

Post by timmydownawell »

phuketrichard wrote: Tue Sep 28, 2021 11:53 am Image
It's funny how Israel was supposedly highly vaccinated and opened up and ZOMG!!111 so many cases the vaccines don't work!!!!! But they're not even in this list of the 22 most vaccinated countries. It just looks like they opened up way too soon and didn't keep sufficient preventative measures in place.
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Re: Covid-19 VACCINE News

Post by AndyKK »

That has got to be a good point, and I would say the main point. Because it looks good for a country who is on a good vaccination roll out, and they become far up the world leaderboard. But if the vaccines they administer don't perform or have a low rating. Well!
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Re: Covid-19 VACCINE News

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Public Health England have announced some figures of people currently undergoing the highest form of treatment, beyond being intubated: ECMO, extra corporeal membrane oxygenation.
During the process their blood is extracted by a heart and lung machine, carbon dioxide is removed and oxygen added and then the treated blood is put back into their bodies in a last-ditch attempt to help them recover their lung function and breathe on their own again.


There were 118 people on ECMO between July and September and the breakdown was: 107 unvaccinated, 4 partially vaccinated and 7 fully vaccinated.

The story was picked up by the Guardian who highlighted that of those 118 people, 20 were pregnant women. The doctors seem to be in agreement; pregnant women should get vaccinated at any stage of pregnancy.

https://www.theguardian.com/lifeandstyl ... with-covid
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Re: Covid-19 VACCINE News

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Covid booster shots important to stop infection, finds English study
Study shows protection against Covid starts to wane several months after full vaccination
Ian Sample Science editor
Thu 14 Oct 2021 06.01 BST

Scientists have urged eligible people to have Covid booster shots after a major survey in England found evidence of “breakthrough infections” more than three months after full vaccination.

Researchers at Imperial College London analysed more than 100,000 swabs from a random sample of the population and found that Covid infection rates were three to four times higher among unvaccinated people than those who had received two shots.

But while full vaccination drove infection rates down substantially, from 1.76% in the unvaccinated to 0.35% in the three months after the second dose, infection rates rose again to 0.55% three to six months after the second shot.

The finding suggests that protection against infection, with or without symptoms, starts to wane several months after full vaccination, though other studies show that vaccine protection against hospitalisation and death is far more robust.

“The possible increase of breakthrough infections over time reinforces the need for a booster programme,” said Paul Elliott, head of the React study and professor in epidemiology and public health medicine at Imperial. “It’s an incentive for people to get their booster dose when it becomes available to them,” added Prof Christl Donnelly, a statistical epidemiologist on the study. The results came as new Covid cases in the UK rose to 42,776, the highest recorded since late July.

The React study has used community testing to provide regular snapshots of the epidemic in England throughout the Covid crisis. The latest data include results from 100,527 swabs provided between 9 and 27 September, and another 98,233 swabs taken in June and July.

All of the viruses sequenced in the study were the highly-transmissible Delta variant, with one sample carrying a mutation called E484K which may help the virus evade immunity from past infection or vaccination. The relative of Delta is being monitored by the UK Health Security Agency.

Preliminary results from the survey, which are not yet peer-reviewed, show that the highest rates of infection in September were among five to 17-year-olds, with about 2.5% testing positive, followed by 35 to 54-year-olds, the age group most likely to have children at school. Efforts to vaccinate healthy 12 to 15-year-olds and provide boosters for those aged 50 and above are now under way.

According to the study full vaccination reduced the risk of infection, with or without symptoms, by about 60%. The Pfizer vaccine appeared to be more effective than AstraZeneca’s, but the vaccines were given to different age groups at different points in the epidemic, so they cannot be directly compared.
https://www.theguardian.com/world/2021/ ... lish-study
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