It's a fact MDMA makes you stay up and be happy...i
Re: It's a fact MDMA makes you stay up and be happy...i
ExactlyFrancis wrote:I'm surely not up for that reason.......all what I was trying to say is........be careful with certain products.......at least get informed what that stuff can do. There is a high risk and good reason to believe that people using this kind of products are going to pay for it, even YEARS after they have quit.
In the days after Ecstasy use, around 80% of users report rebound depression and lethargy, due probably to monoaminergic depletion. Dosage escalation and chronic pharmacodynamic tolerance typically occur in regular users. Repeated doses of MDMA cause serotonergic neurotoxicity in laboratory animals, and there is extensive evidence for long-term neuropsychopharmacological damage in humans. Abstinent regular Ecstasy users often display reduced levels of 5-HT, 5-HIAA, tryptophan hydroxylase and serotonin transporter density; functional deficits in learning/memory, higher cognitive processing, sleep, appetite and psychiatric well-being, and, most paradoxically, ‘loss of sexual interest/pleasure’. These psychobiological deficits are greatest in heavy Ecstasy users and may reflect serotonergic axonal loss in the higher brain regions, especially the frontal lobes, temporal lobes and hippocampus. These problems seem to remain long after the recreational use of Ecstasy has ceased, suggesting that the neuropharmacological damage may be permament.
Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research, A. C. Parrott* (2001)
Further research on the adverse effects of MDMA
http://www.drugabuse.gov/publications/m ... references
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