Clutch Cargo wrote: ↑Thu Mar 31, 2022 9:49 pm

Clutch Cargo wrote: ↑Thu Mar 31, 2022 7:54 pm Final nail in the coffin for Ivermectin?

Major study confirms ivermectin useless against COVID-19

Comprehensive research has confirmed that the drug ivermectin, formerly touted by some as a wonder drug against COVID-19, has no medical benefit in treating the disease.

The TOGETHER study was a major worldwide project involving a series of clinical trials designed to test the effectiveness of a range of drugs against COVID-19.

Full: https://www.brisbanetimes.com.au/nation ... 5a9bp.html

NB The TOGETHER study is funded by charities and NOT pharmaceutical companies..

https://www.togethertrial.com/who-we-are

And who funds the charities?
Follow the money.

Oh give it up. Science > Conspiracy theories.

AndyKK wrote: ↑Thu Mar 31, 2022 9:15 pm Seriously, does anyone know where I can buy some ivermectin? Because most of the pharmacists I have asked have not got any, due to people buying it in large quantities hoping to prevent covid19.
I remember saying some time ago about the drug when needed for what it was meant for would be unavailable.
The thing is I spent some time in the government hospital with my partner, and I ended up with scabies, luckily my partner did not. Apart from using creams from the hospital pharmacy, because even the city centers don't stock them, I am going fuoking crazy because I can't shift them. It's embarrassing and scratch itchy and I don't want to pass them on to anyone, so I am limited to go anywhere.

Pure Invermectin was being sought out for Covid treatment regime. I'd be surprised if anyone gives a shit the stuff now. We are all vaxxed up to the eyeballs and had Covid at least once already.

But the normal deworming medicine is Albendazole and Invermectin combined and they should be readily available.

If you just want Invermectin I have got 12 x3mg tablets you can have for a very reasonable price!

timmydownawell wrote: ↑Fri Apr 01, 2022 11:17 am Oh give it up. Science > Conspiracy theories.

Er, that's a peer reviewed article from the BMJ that you are trying unsuccessfully to argue against.

SternAAlbifrons wrote: ↑Sat Feb 27, 2021 9:59 pm

(one final gift - "millennial" (thanks) I was trading ivory before you were born. 1974, first and last time
but at least I have the brains, heart, and guts to blush about that youthful folly. There is NO excuse these days.
no imo. that is accepted law in most of the world, including for ALL ivory trade in Cambodia
Seriously, start doing your research or you may be caught out for being a just common criminal - not a cool smarty arty ivory and opium pipe connoisseur at all)

Hey buddy. I have not visited this site since my last post to this thread. Remember, I've been here a lot longer than that 1-week experience you had 20 years ago. The locals have been tricking barangs on vacation for years by passing off carved chicken bones as ivory. By all means, enjoy that "tiger tooth" you bought way back though.
In all honestly, I was born in '76. And now that I know your deal I'll settle down when conversing with you. There are major modern laws you're out of the loop on by what little I read of your post. This is off-topic, but let me rock your noggin for a minute. You're going to be shocked to hear this. 39 US states have legalized weed. 19 of them for recreational use too! Legal federally mind you. Don't fall out of your rocker. But if you did, remember to press the button on your Lifecall. Yell, "Help, I've fallen and I can't get up!" I remember those commercials. They did show that someone would actually come. I wouldn't bank on it today though. What a job to have if you were tasked to drive around from place to place picking ppl up. Owning up to that in a bar would be a crowd pleaser for sure. In all seriousness. Those look(ed...?) like sound investments for the elderly. Is the company still around to monitor the cries for help I wonder? Damn, I hope you're still upright.

In some people's situations, I can see how forums can be one's only outlet late in their life. Don't fret, everything has clicked for me now my friend. A good time killer can be spent by someone getting up to speed on current laws too.
I've only broken traffic laws here. When in Rome...
Now that I understand the situation, I can't have anyone thinking negatively of you my man. I've got your back which led me to fix a few of your grammar fails in such a small quote. You know the deal though, nobody can polish a turd no matter how hard they try.

Adios

From the NIH: https://www.nih.gov/about-nih

Ivermectin
Drug Info
Clinical Data
Last Updated: April 29, 2022

Ivermectin is a Food and Drug Administration (FDA)-approved antiparasitic drug used to treat several neglected tropical diseases, including onchocerciasis, helminthiases, and scabies.1 For these indications, ivermectin has been widely used and is generally well-tolerated.1,2 Ivermectin is not approved by the FDA for the treatment of any viral infection.

Proposed Mechanism of Action and Rationale for Use in Patients With COVID-19
Reports from in vitro studies suggest that ivermectin acts by inhibiting host importin alpha/beta-1 nuclear transport proteins, which are part of a key intracellular transport process.3,4 Viruses hijack the process and enhance infection by suppressing the host’s antiviral response. In addition, ivermectin docking may interfere with SARS-CoV-2 spike protein attachment to the human cell membrane.5 Some studies of ivermectin have also reported potential anti-inflammatory properties, which have been postulated to be beneficial in people with COVID-19.6-8

Ivermectin has been shown to inhibit replication of SARS-CoV-2 in cell cultures.9 However, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans.10,11 Although ivermectin appears to accumulate in lung tissue, predicted systemic plasma and lung tissue concentrations are much lower than 2 µM, the half-maximal inhibitory concentration (IC50) observed in vitro for ivermectin against SARS-CoV-2.12-15 Subcutaneous administration of ivermectin 400 µg/kg had no effect on SARS-CoV-2 viral loads in hamsters.16 However, there was a reduction in olfactory deficit (measured using a food-finding test) and a reduction in the interleukin (IL)-6:IL-10 ratio in lung tissues.

The safety and efficacy of ivermectin for the prevention and treatment of COVID-19 have been evaluated in clinical trials and observational cohorts. Summaries of the studies that informed The COVID-19 Treatment Guidelines Panel’s (the Panel) recommendation can be found in Table 2d. The Panel reviewed additional studies, but these studies are not summarized in Table 2d because they have study design limitations or results that make them less definitive and informative.
Recommendation

The Panel recommends against the use of ivermectin for the treatment of COVID-19, except in clinical trials (AIIa).

Rationale
The results of several randomized trials and retrospective cohort studies of ivermectin use in patients with COVID-19 have been published in peer-reviewed journals or have been made available as manuscripts ahead of peer review. Most of these studies, especially studies completed earlier in the pandemic, had incomplete information and significant methodological limitations, which made excluding common causes of bias difficult. Many of these studies have not been peer reviewed, and some have now been retracted.

The Panel’s recommendation is primarily informed by recently published randomized controlled trials.17-20 The primary outcomes of these trials showed that the use of ivermectin for the treatment of COVID-19 had no clinical benefit.
In TOGETHER, an adaptive platform trial conducted in Brazil, there was no apparent difference between the ivermectin and placebo arms for the primary outcome of risk of emergency department visits or hospitalization (14.7% vs. 16.4%). Also, there was no statistically significant difference between the ivermectin and placebo arms in mortality (3.1% vs. 3.5%).
https://www.covid19treatmentguidelines. ... vermectin/

Quelle surprise !!

A 'government' body almost exclusively funded by big pharma finds a ridiculously inexpensive drug not under patent by the big players doesn't work ....

Remember when the FDA thought Thalidomide was good for pregnant woman to combat nausea and AZT was the answer for the Aids epidemic .....

Nope , best to keep to the regime of continually getting vaccine shots that don't halt transmission; or infection ..... But apparently 'minimize symptoms' in certain demographics ......






quote=CEOCambodiaNews post_id=554769 time=1658409440 user_id=853]
From the NIH: https://www.nih.gov/about-nih

Ivermectin
Drug Info
Clinical Data
Last Updated: April 29, 2022

Ivermectin is a Food and Drug Administration (FDA)-approved antiparasitic drug used to treat several neglected tropical diseases, including onchocerciasis, helminthiases, and scabies.1 For these indications, ivermectin has been widely used and is generally well-tolerated.1,2 Ivermectin is not approved by the FDA for the treatment of any viral infection.

Proposed Mechanism of Action and Rationale for Use in Patients With COVID-19
Reports from in vitro studies suggest that ivermectin acts by inhibiting host importin alpha/beta-1 nuclear transport proteins, which are part of a key intracellular transport process.3,4 Viruses hijack the process and enhance infection by suppressing the host’s antiviral response. In addition, ivermectin docking may interfere with SARS-CoV-2 spike protein attachment to the human cell membrane.5 Some studies of ivermectin have also reported potential anti-inflammatory properties, which have been postulated to be beneficial in people with COVID-19.6-8

Ivermectin has been shown to inhibit replication of SARS-CoV-2 in cell cultures.9 However, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans.10,11 Although ivermectin appears to accumulate in lung tissue, predicted systemic plasma and lung tissue concentrations are much lower than 2 µM, the half-maximal inhibitory concentration (IC50) observed in vitro for ivermectin against SARS-CoV-2.12-15 Subcutaneous administration of ivermectin 400 µg/kg had no effect on SARS-CoV-2 viral loads in hamsters.16 However, there was a reduction in olfactory deficit (measured using a food-finding test) and a reduction in the interleukin (IL)-6:IL-10 ratio in lung tissues.

The safety and efficacy of ivermectin for the prevention and treatment of COVID-19 have been evaluated in clinical trials and observational cohorts. Summaries of the studies that informed The COVID-19 Treatment Guidelines Panel’s (the Panel) recommendation can be found in Table 2d. The Panel reviewed additional studies, but these studies are not summarized in Table 2d because they have study design limitations or results that make them less definitive and informative.
Recommendation

The Panel recommends against the use of ivermectin for the treatment of COVID-19, except in clinical trials (AIIa).

Rationale
The results of several randomized trials and retrospective cohort studies of ivermectin use in patients with COVID-19 have been published in peer-reviewed journals or have been made available as manuscripts ahead of peer review. Most of these studies, especially studies completed earlier in the pandemic, had incomplete information and significant methodological limitations, which made excluding common causes of bias difficult. Many of these studies have not been peer reviewed, and some have now been retracted.

The Panel’s recommendation is primarily informed by recently published randomized controlled trials.17-20 The primary outcomes of these trials showed that the use of ivermectin for the treatment of COVID-19 had no clinical benefit.
In TOGETHER, an adaptive platform trial conducted in Brazil, there was no apparent difference between the ivermectin and placebo arms for the primary outcome of risk of emergency department visits or hospitalization (14.7% vs. 16.4%). Also, there was no statistically significant difference between the ivermectin and placebo arms in mortality (3.1% vs. 3.5%).
https://www.covid19treatmentguidelines. ... vermectin/
[/quote]

you can not debate it, and then call it follow the science.
guess soon you will scrap it of the net to...

https://finance.yahoo.com/news/fda-misl ... OBMFEuWk6-